Tap Forms 5.3.33

These data suggested that the peptidases might interact physically. To address this possibility, we first analyzed the molecular sizes of the peptidases in microsome extracts by zonal sedimentation analysis (Fig. 3a). Although the bulk of the enzymes sedimented in the fractions corresponding to the molecular weight of a single peptidase molecule of about 120 kDa, a small proportion of each enzyme had a molecular size of about twice this value. The higher-molecular-weight forms most likely correspond to heterodimers of ERAP1 and ERAP2, but may also correspond to homodimers of each enzyme or reflect association of the enzymes with unidentified 'third-party' proteins.

Tap Forms 5.3.33

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